| Effector Protein ID: 52842358 |
 T4SS name [ID] | Dot/Icm [5] |
| Gene symbol | legAU13 |
| Locus tag | lpg2144 |
| Strain | Legionella pneumophila subsp. pneumophila str. Philadelphia 1 |
| Replicon | chromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon] |
| Location [Strand] | 2390645..2391163 [+] |
| Product | F-box protein |
| Effector type | Protein |
| Descripton | AnkB/legAU13/ceg27 |
| T4CP requirement | T4CP Depedent |
| Target/Effection | AnkB is essential for Legionella-containing vacuole (LCV) acquisition of polyubiquitinated proteins in both macrophage and amoeba hosts |
| UniProt ID | Q5ZTL7 |
| KEGG ID | lpn:lpg2144 |
| PDB ID | NA |
| Domain hit(s) vs Pfam | Ank_2 [PF12796], Evalue: 5.1e-16, Aligned region: 62..122 Ank_2 [PF12796], Evalue: 5.1e-16, Aligned region: 63..134 Ank_4 [PF13637], Evalue: 9.3e-09, Aligned region: 61..113 F-box-like [PF12937], Evalue: 1.3e-06, Aligned region: 6..44 |
| Protein Sequence: 172 a.a. [Download] |
| >gi|52842358|ref|YP_096157.1| F-box protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1] MKKNFFSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHLELHQLRQQHIKRELWGNLMVAARSN NLEEVKKILKKGIDPTQTNSYHLNRTPLLAAIEGKAYQTANYLWRKYTFDPNFKDNYGDSPISLLKKQLA NPAFKDKEKKQIRALIRGMQEEKIAQSKCLVC |
| - |
| Nucleotide Sequence: 519 bp [Download] |
| >gi|52840256|ref|NC_002942.5|:2390645-2391163 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome ATGAAAAAGAATTTTTTTTCTGATCTTCCTGAGGAAACAATTGTCAATACATTGAGTTTCTTAAAAGCAA ACACACTAGCTCGTATAGCTCAGACATGTCAATTTTTTAATCGCTTGGCTAATGATAAACATCTGGAGCT GCATCAACTAAGACAACAGCATATAAAGCGAGAGCTATGGGGAAATCTTATGGTGGCGGCAAGAAGCAAT AACCTGGAAGAGGTCAAAAAGATTCTAAAAAAAGGAATCGATCCAACCCAGACCAATAGCTACCACTTAA ATAGAACGCCTTTACTTGCAGCTATCGAAGGAAAAGCATATCAAACTGCAAATTACCTCTGGAGAAAATA CACTTTCGATCCCAATTTTAAAGATAACTATGGTGATTCACCTATCTCTCTTCTTAAAAAGCAACTGGCA AATCCAGCCTTCAAGGATAAGGAAAAAAAACAAATACGCGCCTTAATTAGGGGAATGCAAGAAGAAAAAA TAGCACAGAGCAAGTGCCTTGTTTGTTAA |
| Reference |
| (1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890] |
(2) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] 
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(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] 
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| experimental literature |
| in silico analysis literature |