SecReT4
Effector Protein ID: 52842180
T4SS name [ID]Dot/Icm [5]
Gene symbol-
Locus taglpg1963
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2196799..2198898 [-]
Producthypothetical protein
Effector typeProtein
DescriptonPieA/lirC
T4CP requirementT4CP Depedent
Target/EffectionPieA is recruited to the cytoplasmic face of the LCV and overexpression alters lysosome morphology through an unknown mechanism. (Ge and Shao, 2011)
UniProt IDQ5ZU45
KEGG IDlpn:lpg1963
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 699 a.a.     [Download]
>gi|52842180|ref|YP_095979.1| hypothetical protein lpg1963 [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MQEKIINLGKGLKKVNEGIKKHISRAEEFLYLANQWEKENIKINDLLNGVQFTVNDKKMSGQEIKEELSN
LIERYNNFLKKNLKGERSETLELKEIQQQLTNLYNAVNDIYTYLSINKTEFFLEAIKSCYKKDQRMGSTI
QFVLKIADHLSKERLQFNLNLNSQFAEASESFQEVTTKFYREVATPRIESAQKLLELMNNFVDQYISQGA
SPEDAIKKLKPFEKYFTIEISHYEEFGHLVYKTNFNCNPALFDVNPIEFLNELFVQFYKDTTLSSRSKTA
LKQVLDKFEITYEVPKTWYGYIGWDIPIVTDKNSVLVTYDKQAYYRYHQESGQREMEFFETIERCLDKSK
DIIIATKKENLKDQKEFSKLIDKAIKELEETKKKRIFQKEPHELVTSIINKSIKLLQDLKNNMPLRREDL
VMVILSTENALNAAKSKLKPQEINLSEPEKCIKNFKKILAIKQKEELCFYKSDEEQSIFSKHINSELREL
VESYQVQKRSEKELVIEPEKMNSPQRIEPKEEDKKIDLNKKMNLYRVQKIMKNFVFEYCGYKGGKKVKEG
GATIEELKNKLKDFRDYFQIEIVMNDKSGSEELNIIFNYQNIKNKNPHDLFNELFKKFTEDIGYSGMGSR
SIEALKRALAKNNITYTNGYYGKTATLTSLLWSKEPPVITDEKNIFKLSDEKHLSENKEDIRGKGITNI
-
Nucleotide Sequence: 2100 bp     [Download]
>gi|52840256|ref|NC_002942.5|:c2198898-2196799 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGCAAGAAAAAATTATCAACTTAGGGAAAGGGCTTAAAAAGGTTAATGAAGGCATTAAAAAACATATTT
CCCGAGCAGAAGAGTTCCTCTACTTGGCGAACCAATGGGAAAAAGAGAATATTAAGATTAATGATTTATT
GAATGGAGTGCAGTTTACAGTTAATGATAAAAAAATGTCGGGTCAAGAAATTAAAGAAGAACTATCTAAT
CTAATAGAAAGATATAATAATTTTCTAAAAAAAAACTTAAAAGGGGAAAGAAGCGAAACATTAGAACTAA
AGGAGATTCAGCAACAACTTACTAATTTATACAATGCTGTTAATGATATTTATACTTATTTATCCATAAA
TAAAACAGAGTTTTTTCTCGAAGCAATCAAGTCTTGCTATAAAAAAGATCAGAGGATGGGTAGTACAATC
CAGTTTGTGCTGAAGATCGCGGATCATCTTTCTAAGGAGAGACTGCAATTTAATTTGAATTTAAATTCGC
AATTTGCAGAAGCCTCCGAGAGTTTTCAGGAGGTAACTACCAAATTTTACAGAGAGGTTGCTACTCCTAG
AATAGAATCTGCACAAAAATTGTTGGAATTGATGAATAATTTCGTAGACCAATATATATCACAAGGAGCA
AGTCCAGAAGATGCAATAAAAAAACTTAAGCCATTTGAGAAATATTTTACTATTGAAATCTCGCATTATG
AAGAGTTTGGGCATTTAGTATATAAAACAAACTTTAATTGTAATCCAGCGCTATTTGATGTTAACCCCAT
TGAATTTTTAAATGAATTATTTGTGCAATTTTATAAAGACACCACTTTATCATCTCGCTCTAAAACAGCT
TTAAAACAAGTGCTTGATAAATTTGAGATTACTTATGAGGTGCCAAAGACATGGTATGGTTATATTGGCT
GGGATATCCCTATAGTAACTGATAAAAATTCAGTATTAGTTACTTATGACAAACAAGCTTATTACAGATA
TCATCAAGAAAGCGGCCAGAGAGAAATGGAGTTTTTTGAGACAATTGAGCGCTGTTTGGATAAGTCGAAA
GACATTATTATTGCGACTAAAAAGGAAAATTTAAAAGACCAAAAAGAGTTTTCTAAATTGATAGATAAGG
CTATTAAGGAGTTAGAAGAAACAAAAAAGAAAAGAATTTTTCAAAAGGAGCCGCATGAATTGGTAACAAG
TATTATCAATAAATCAATAAAGTTGCTGCAAGACTTGAAAAATAATATGCCATTAAGACGAGAAGATTTG
GTCATGGTAATCTTAAGTACTGAAAATGCTTTAAATGCAGCAAAATCAAAATTAAAGCCACAAGAAATCA
ATTTATCCGAACCGGAAAAATGCATTAAAAATTTTAAAAAGATATTAGCAATAAAACAGAAAGAAGAGCT
TTGTTTTTATAAATCAGATGAAGAACAATCTATTTTCTCCAAACACATAAATTCTGAGCTTAGAGAACTT
GTCGAATCTTACCAGGTTCAAAAGAGAAGTGAAAAAGAGTTGGTTATTGAGCCAGAAAAAATGAATTCAC
CACAGAGAATAGAACCAAAAGAAGAAGATAAAAAGATTGATTTAAATAAGAAAATGAATTTATACCGTGT
TCAAAAAATTATGAAAAATTTTGTATTTGAGTATTGCGGGTATAAGGGAGGGAAAAAAGTAAAAGAGGGA
GGAGCAACAATAGAAGAACTTAAAAATAAACTCAAAGATTTTAGAGATTATTTTCAAATAGAGATAGTGA
TGAATGATAAAAGTGGTTCAGAAGAACTCAATATCATATTCAACTATCAAAACATCAAGAATAAAAATCC
ACATGATTTATTTAATGAGCTCTTTAAAAAATTTACCGAAGACATAGGATATTCTGGTATGGGTTCACGA
TCAATCGAGGCTCTTAAAAGAGCATTAGCTAAAAATAATATCACTTATACCAATGGATATTATGGAAAAA
CAGCGACTTTAACAAGCCTATTATGGAGTAAAGAGCCACCTGTTATTACTGATGAAAAAAATATATTTAA
ATTATCCGATGAAAAGCATTTAAGTGAGAATAAGGAAGATATTCGCGGAAAAGGAATTACGAATATCTAG

Reference
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(3) Zusman T; Degtyar E; Segal G (2008). Identification of a hypervariable region containing new Legionella pneumophila Icm/Dot translocated substrates by using the conserved icmQ regulatory signature. Infect Immun. 76(10):4581-91. [PudMed:18694969] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature