SecReT4
Effector Protein ID: 52842167
T4SS name [ID]Dot/Icm [5]
Gene symbolsec7
Locus taglpg1950
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]2178619..2179743 [+]
Productguanine nucleotide exchange protein
Effector typeProtein
DescriptonRalF
T4CP requirementT4CP Depedent
Target/EffectionRalF mediates Legionella-containing vacuole (LCV) recruitment of Arf1 (ADP-ribosylation factor 1), which is a GTPase responsible for mediating vesicular transport between Golgi and endoplastic reticulum. RalF colocalizes with Arf1 and activates it on the LCV after bacterial internalization
UniProt IDQ5ZU58
KEGG IDlpn:lpg1950
PDB IDNA
Domain hit(s) vs Pfam Sec7 [PF01369], Evalue: 1.7e-56, Aligned region: 9..192
Protein Sequence: 374 a.a.     [Download]
>gi|52842167|ref|YP_095966.1| guanine nucleotide exchange protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MHPEIEKAQREIIEAFNAKPKNGINKIKEICEQYKISPNEEIAEFFHQQRKNLDLEAVGDYLSSPEAENQ
QVLKAFTSQMNFNGQSFVEGLRTFLKTFKLPGEAQKIDRLVQSFSGAYFQQNPDVVSNADAAYLLAFQTI
MLNTDLHNPSIPEKNKMTVDGLKRNLRGGNNGGDFDAKFLEELYSEIKAKPFELNFVKTSPGYELTSTTL
NKDSTFKKLDSFLHSTDVNINTVFPGIGDNVKTTVDQPKSWLSFFTGYKGTITLTDNKTSAQATIQVYTP
NIFSKWLFGEQPRVIIQPGQTKESIDLAAKAAADFSSPVKNFKATYDYEVGDLIKAYDNQKKLITIERNL
ALKEGVPKDPDAEMQKEKGRQLKF
-
Nucleotide Sequence: 1125 bp     [Download]
>gi|52840256|ref|NC_002942.5|:2178619-2179743 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGCATCCAGAAATTGAAAAAGCCCAAAGAGAGATTATTGAGGCATTCAATGCCAAGCCAAAAAATGGGA
TAAATAAAATAAAAGAAATATGTGAACAATATAAAATTTCTCCCAATGAAGAGATAGCTGAGTTCTTTCA
TCAACAAAGAAAAAATTTGGATTTAGAAGCGGTTGGCGATTATTTAAGCAGCCCAGAGGCAGAAAACCAG
CAAGTATTAAAAGCTTTTACCAGTCAAATGAATTTCAATGGGCAAAGTTTTGTTGAGGGTTTAAGGACCT
TTTTGAAAACATTTAAATTACCAGGCGAAGCTCAAAAAATTGACCGGTTAGTGCAAAGCTTTAGTGGTGC
CTATTTCCAGCAAAATCCTGATGTGGTTTCCAATGCGGATGCTGCCTATCTTTTAGCATTTCAAACCATT
ATGCTTAATACTGATTTACATAACCCAAGTATCCCTGAGAAAAATAAAATGACCGTGGATGGACTCAAAA
GAAATCTCAGAGGAGGTAATAATGGTGGAGATTTTGATGCCAAATTTTTAGAGGAACTATACAGTGAGAT
TAAAGCCAAACCTTTTGAGTTGAATTTCGTTAAAACCAGCCCAGGATATGAACTTACTTCAACCACTCTT
AATAAAGATTCTACCTTTAAAAAGCTGGATTCATTCTTGCATTCAACGGATGTAAACATCAATACAGTTT
TTCCAGGAATAGGTGATAATGTTAAAACAACTGTAGATCAACCAAAATCATGGTTAAGTTTTTTTACCGG
ATATAAGGGAACAATAACGTTGACAGATAACAAAACATCCGCACAAGCTACTATCCAGGTTTATACTCCC
AATATATTTTCAAAATGGCTATTTGGAGAACAACCGAGAGTAATAATACAACCTGGACAAACCAAAGAGT
CAATCGATTTGGCAGCAAAAGCAGCAGCTGACTTTTCATCGCCAGTAAAAAATTTTAAAGCGACGTATGA
TTATGAGGTAGGTGATTTAATAAAAGCATATGATAACCAGAAAAAACTCATTACGATTGAGAGAAACCTG
GCACTTAAGGAGGGCGTTCCCAAAGATCCAGACGCTGAAATGCAAAAAGAAAAAGGTAGACAATTAAAAT
TTTAA

Reference
(1) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(2) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(3) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
(4) Tiaden A; Spirig T; Carranza P; Bruggemann H; Riedel K; Eberl L; Buchrieser C; Hilbi H (2008). Synergistic contribution of the Legionella pneumophila lqs genes to pathogen-host interactions. J Bacteriol. 190(22):7532-47. [PudMed:18805977] experimental
(5) Pan X; Luhrmann A; Satoh A; Laskowski-Arce MA; Roy CR (2008). Ankyrin repeat proteins comprise a diverse family of bacterial type IV effectors. Science. 320(5883):1651-4. [PudMed:18566289] experimental in_silico
(6) Cambronne ED; Roy CR (2007). The Legionella pneumophila IcmSW complex interacts with multiple Dot/Icm effectors to facilitate type IV translocation. PLoS Pathog. 3(12):e188. [PudMed:18069892] experimental
(7) Shi C; Forsbach-Birk V; Marre R; McNealy TL (2006). The Legionella pneumophila global regulatory protein LetA affects DotA and Mip. Int J Med Microbiol. 296(1):15-24. [PudMed:16423685] experimental
 
experimental experimental literature
in_silico in silico analysis literature