SecReT4
Effector Protein ID: 52841718
T4SS name [ID]Dot/Icm [5]
Gene symbollegC5
Locus taglpg1488
StrainLegionella pneumophila subsp. pneumophila str. Philadelphia 1
Repliconchromosome [GenBank: NC_002942] [Browse all T4SS(s) in this replicon]
Location [Strand]1642834..1645431 [+]
Productcoiled-coil-containing protein
Effector typeProtein
DescriptonLgt3/legc5
T4CP requirementT4CP Depedent
Target/EffectionLgt3 is important for initiation of infection cycle (Belyi, et al. 2011)
UniProt IDQ5ZVF2
KEGG IDlpn:lpg1488
PDB IDNA
Domain hit(s) vs Pfam NA
Protein Sequence: 865 a.a.     [Download]
>gi|52841718|ref|YP_095517.1| coiled-coil-containing protein [Legionella pneumophila subsp. pneumophila str. Philadelphia 1]
MKEQQKAIFIENIKSTCAVDEQMAKELADSLLEIHQLNTGVNEQTLINEVFLTKFALYLKIGKEVALDWV
RKNKDLDTPFPSNTVENQPAQDAKKPVENKVQVYGAMTVGSSPVNKTLNRLTNDLLKEVVERGKTQKAQK
LRAYIFDQLARRLEASLSQEQINDLYNRIRGTGDYTKSESFSEEQLKILKEKVVPELKRELSDLSNGNVN
ILGLDVSREDKYAFDTTNIFSVWFSNNPAVYMPQHVKTQVEKTAKLNQPGKTRIVFSSLCLNETAQIDFQ
QWAKENNIELVDIDSIDLKSVSETDAQLLNLAKDELGAMRKGKGGNPAAASDLVRWVDVIIGESSTYIDI
DLPMNDKKVTVEVHSGFPVLLNMGSALTKDGQQPAMENPAFNTDMIAYSKDKEARRQIIEGVAKKIIARY
ENCAKYIEESKNEELVRLKNSPGYKLFVEKTDGKFDLCTLRAAVSEAHQDALSFATFFGAEYFAKTFATQ
ELIPVIKEAIQHQNQDLLTSVIENHIEKQHLNDYPKTPDGIKKLLKSFQGIVYKPLVMEFSGPSAVSSSW
VEAISGRSIPRNFEYLAEPMSQPLRVLQHYACVSGKANFSSDNIPKWCELQSDVEKRQQQREDGLSWLPD
AQEKLKREGQQAKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKLEEEQRIKL
EEEQRIKLEEEQRIKLEEEHKSKKYFAQSDAIDLILNNFENEINSIGAYYAPAKQRAIELLDTLRKYKEE
AFNDPSREKLISFAQSTKRAIQEATPILQKDLGWGDYLTNLAKQLVNAVTFAVAYAVTFGTTGHQGFFAL
KSSLAVSQSQNLEGAINSELSQKNC
-
Nucleotide Sequence: 2598 bp     [Download]
>gi|52840256|ref|NC_002942.5|:1642834-1645431 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 chromosome, complete genome
ATGAAAGAGCAACAAAAGGCAATTTTTATTGAGAATATCAAATCGACATGCGCTGTTGACGAGCAAATGG
CTAAAGAATTGGCTGATTCATTGCTTGAAATTCACCAGTTAAACACTGGAGTTAATGAACAAACACTGAT
TAATGAGGTGTTTTTAACTAAATTTGCTCTCTATCTTAAAATTGGGAAAGAGGTTGCTTTAGATTGGGTT
CGAAAAAATAAGGACTTGGATACTCCCTTTCCTTCTAATACAGTCGAAAATCAGCCTGCTCAAGATGCGA
AAAAGCCTGTTGAGAACAAGGTTCAAGTATATGGAGCTATGACAGTTGGCAGTTCTCCTGTTAATAAGAC
TTTAAATCGATTAACCAATGATCTTTTGAAAGAGGTCGTTGAACGTGGAAAGACTCAGAAAGCTCAAAAA
TTACGAGCTTACATATTCGATCAATTGGCAAGGCGATTAGAAGCTTCGCTTAGCCAAGAGCAGATTAACG
ATTTATATAACAGAATAAGAGGCACTGGTGACTATACTAAAAGCGAATCATTTTCCGAAGAACAACTTAA
AATTTTAAAAGAAAAAGTTGTTCCAGAATTAAAGAGAGAGCTAAGTGACCTCAGCAACGGGAATGTTAAT
ATTCTGGGGTTGGACGTTAGTCGTGAAGATAAATACGCATTTGATACAACCAATATATTTTCTGTCTGGT
TTAGTAATAACCCAGCAGTTTACATGCCACAACATGTTAAAACTCAAGTAGAAAAAACTGCAAAACTTAA
CCAGCCAGGCAAAACTCGAATTGTTTTTAGCTCATTATGCTTGAATGAGACTGCACAGATTGATTTTCAG
CAATGGGCAAAGGAAAACAACATTGAATTGGTTGATATAGATTCAATAGATTTAAAATCAGTCAGTGAAA
CTGATGCTCAATTGCTAAATCTAGCCAAAGATGAACTTGGAGCAATGAGAAAGGGCAAGGGAGGAAATCC
TGCCGCAGCATCTGATCTGGTGCGTTGGGTTGATGTAATCATTGGAGAAAGCAGTACTTATATTGATATT
GATTTACCAATGAATGATAAAAAAGTCACAGTTGAGGTTCATTCCGGTTTCCCAGTTCTACTTAATATGG
GGTCAGCGCTCACAAAGGATGGTCAACAGCCTGCTATGGAAAACCCGGCTTTCAATACTGATATGATTGC
TTATAGCAAAGATAAAGAGGCACGTCGTCAAATAATCGAGGGGGTTGCCAAAAAGATCATTGCGCGTTAT
GAAAACTGCGCGAAATATATTGAGGAAAGCAAAAACGAAGAGTTAGTACGTTTAAAAAATTCACCAGGTT
ATAAATTATTTGTTGAAAAAACAGATGGCAAATTTGATTTATGTACTTTAAGGGCGGCGGTTTCAGAAGC
TCACCAGGATGCTTTGTCGTTTGCAACTTTTTTTGGCGCTGAGTATTTTGCTAAAACTTTTGCTACACAA
GAACTTATACCTGTAATTAAAGAGGCAATTCAGCATCAAAATCAAGATTTGCTTACATCTGTTATTGAAA
ATCATATAGAAAAACAACATCTCAATGACTATCCTAAGACTCCCGATGGCATTAAAAAACTATTGAAGTC
GTTTCAAGGGATTGTCTATAAACCATTGGTTATGGAATTCTCAGGCCCAAGTGCCGTCTCATCATCTTGG
GTGGAAGCTATATCTGGAAGATCCATCCCGAGAAATTTTGAATATTTAGCTGAACCTATGTCTCAACCAT
TACGAGTTTTACAGCATTATGCCTGTGTATCTGGAAAAGCTAATTTTTCTTCTGATAACATTCCTAAATG
GTGTGAACTTCAGTCTGACGTAGAAAAACGACAACAACAAAGAGAAGATGGACTTTCCTGGCTTCCTGAT
GCTCAAGAGAAGCTTAAGAGGGAAGGGCAGCAAGCCAAACTTGAGGAAGAGCAACGAATCAAACTTGAGG
AAGAGCAACGAATCAAACTTGAGGAAGAGCAACGAATCAAACTTGAGGAAGAGCAACGAATCAAACTTGA
GGAAGAACAACGAATCAAACTTGAGGAAGAACAACGAATCAAACTTGAGGAAGAACAACGAATCAAACTT
GAGGAAGAACAACGAATCAAACTTGAGGAAGAGCAACGAATCAAACTTGAGGAAGAGCACAAAAGCAAAA
AATACTTTGCTCAGTCCGATGCTATTGATCTCATTTTGAATAATTTCGAAAATGAAATTAACTCTATTGG
TGCTTATTATGCCCCTGCAAAACAAAGAGCTATAGAATTGCTAGATACTTTGAGAAAATATAAAGAGGAA
GCATTTAATGATCCAAGCAGAGAAAAATTAATCTCTTTTGCGCAAAGTACAAAAAGAGCAATTCAGGAAG
CAACACCAATACTGCAAAAAGATTTAGGCTGGGGAGATTATTTAACCAATTTAGCGAAACAATTGGTTAA
TGCAGTGACCTTTGCTGTGGCTTATGCTGTAACTTTTGGAACCACCGGGCATCAAGGCTTTTTTGCTTTG
AAATCTTCTCTGGCGGTTAGTCAATCTCAAAATCTTGAAGGGGCAATCAATAGCGAATTGAGTCAAAAAA
ACTGTTAG

Reference
(1) Rolando M; Buchrieser C (2012). Post-translational modifications of host proteins by Legionella pneumophila: a sophisticated survival strategy. Future Microbiol. 7(3):369-81. [PudMed:22393890]
(2) Tzivelekidis T; Jank T; Pohl C; Schlosser A; Rospert S; Knudsen CR; Rodnina MV; Belyi Y; Aktories K (2011). Aminoacyl-tRNA-charged eukaryotic elongation factor 1A is the bona fide substrate for Legionella pneumophila effector glucosyltransferases. PLoS One. 6(12):e29525. [PudMed:22216304] experimental
(3) Gomez-Valero L; Rusniok C; Cazalet C; Buchrieser C (2011). Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions. Front Microbiol. 2:208. [PudMed:22059087] in_silico
(4) Luo ZQ (2012). Legionella secreted effectors and innate immune responses. Cell Microbiol. 14(1):19-27. [PudMed:21985602]
(5) Fontana MF; Banga S; Barry KC; Shen X; Tan Y; Luo ZQ; Vance RE (2011). Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila. PLoS Pathog. 7(2):e1001289. [PudMed:21390206] experimental
(6) Burstein D; Zusman T; Degtyar E; Viner R; Segal G; Pupko T (2009). Genome-scale identification of Legionella pneumophila effectors using a machine learning approach. PLoS Pathog. 5(7):e1000508. [PudMed:19593377] experimental in_silico
 
experimental experimental literature
in_silico in silico analysis literature